South Carolina Democrat Annie Andrews Launches Bid to Unseat Sen. Lindsey Graham

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Annie Andrews, a Democratic pediatrician who ran for Congress unsuccessfully in 2022, is launching a Senate bid in the hopes of toppling GOP Sen. Lindsey Graham, a mainstay of South Carolina’s GOP who has served in elected office in the state for more than 30 years. Andrews played up her background in a launch video, and in a conversation with NBC News on Monday before her launch where she said Democrats “need to meet people where they are [and] talk like regular people to regular people, which is why we need regular people like me, a mom and a pediatrician, to run.” Andrews was deeply critical of Graham’s record, and his growing fondness for Trump after spending much of his 2016 presidential campaign warning against Trump’s influence on the GOP.

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Sen. Lindsey Graham gets a 2026 challenge from Democrat Annie Andrews, who ran against Nancy Mace

Dr. Annie Andrews, the South Carolina Democrat who unsuccessfully challenged U.S. Rep. Nancy Mace in 2022, says she’s running against Republican U.S. Sen. Lindsey Graham in 2026, challenging the four-term incumbent in part due to what she characterized as his waffling positions over the course of his political career. “He’s changed his position on nearly every issue over that time and that’s because, in my view, he doesn’t stand for anything or believe in anything other than what it takes to get reelected,” Andrews, a pediatrician in Charleston, told The Associated Press before a campaign rollout Thursday. Andrews joins at least one other Democrat in a primary field.

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Fox News
Lindsey Graham draws Democratic Senate challenger who previously lost congressional race

A South Carolina pediatrician and former Democratic House candidate announced Wednesday that she is now running to replace Republican Sen. Lindsey Graham in the upper chamber of Congress. Dr. Annie Andrews, who lost by about 14 percentage points to Mace in the 2022 election, announced her campaign through a roughly three-and-a-half-minute political ad in which she describes Graham as "full of s---." Andrews, wearing scrubs and seen interacting with young patients, says she has been a pediatrician in South Carolina for about two decades, and that parents trust her to "treat their kids for just about everything you can imagine."

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Sen. Lindsey Graham gets a 2026 challenge from Democrat Annie Andrews, who ran against Nancy Mace
Andrews says it's "embarrassing" to see how politicians like Graham have swung from criticizing Trump to working to gain his favor. She calls Defense Secretary Pete Hegseth "a guy who can't even organize a text thread" No Democrat has won a U.S. Senate seat in South Carolina in decades.
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Sen. Lindsey Graham gets a 2026 challenge from Democrat Annie Andrews, who ran against Nancy Mace
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South Carolina Democrat Dr. Annie Andrews launches US Senate bid against Lindsey Graham
Annie Andrews, a pediatrician, lost a closely watched U.S. House race in 2022. She is the fourth Democrat to join a growing field of contenders vying to defy long odds in ruby-red South Carolina. No Democrat has won a statewide race in the Palmetto State since 2006.
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Democrat Dr. Annie Andrews to challenge Lindsey Graham for U.S. Senate seat in South Carolina
Annie Andrews is running for U.S. Senate from South Carolina. She is challenging Republican Sen. Lindsey Graham, who she says has been too cozy with the White House. She says she wants to change the direction of the country, not the way it's done.
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Pediatrician Annie Andrews challenges Lindsey Graham in South Carolina
Annie Andrews, a pediatrician and former congressional candidate, is launching a Democratic bid to challenge Sen. Lindsey Graham (R-S.C.) next year. In her roughly three-and-a-half-minute ad, …
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Sen. Lindsey Graham gets a 2026 challenge from Democrat Annie Andrews, who ran against Nancy Mace
Annie Andrews is challenging Republican Sen. Lindsey Graham in 2026. She says Graham has changed his position on nearly every issue over the course of his career. Andrews joins at least one other Democrat in a primary field for Graham's seat. The race is expected to be a close one.
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Lowcountry Democrat and pediatrician Dr. Annie Andrews enters SC Senate race
Lowcountry Democrat and pediatrician Dr. Annie Andrews enters SC Senate race. Andrews most recently ran against Rep. Nancy Mace in a race for the 1st Congressional District seat. She says she is running because she wants to “take on Lindsey Graham and the BS in Washington’
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Former MUSC pediatrician announces campaign to oust Lindsey Graham
Annie Andrews, a Mount Pleasant pediatrician, announced she will be running against Lindsey Graham on Thursday, May 29, 2025. Andrews spent 15 years at the Medical University of South Carolina. She attempted in 2022 to oust U.S. Rep. Nancy Mace, is the second Democrat to announce a bid to topple Graham.
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Democratic pediatrician jumps into race against Lindsey Graham
Annie Andrews is a longtime pediatrician in the South Carolina Lowcountry. She's running against Lindsey Graham, the senior US senator from the state. Andrews insists this time will be different: “2026 is going to be a very different year than 2020.”
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This SC pediatrician ran for Congress in 2022. Now she wants to oust Sen. Graham
Annie Andrews is running for U.S. Senate in South Carolina. She ran for Congress in 2022 but lost to a Republican congresswoman. Andrews is the founder and CEO of the Their Future PAC, which is “The first & only PAC” in the state.
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Pediatrician Annie Andrews challenges Lindsey Graham in South Carolina
Annie Andrews, a pediatrician and former congressional candidate, is launching a Democratic bid to challenge Sen. Lindsey Graham (R-S.C.) next year. Andrews described Graham as being ideologically inconsistent and suggested he prioritize the business and donor community over that of everyday Americans. Her campaign ad reminds voters of Graham’s past criticism of Trump, playing several clips of Graham calling the president a “kook”
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Poll:Lindsey Graham Vulnerable in Home State of South Carolina Primary
The Lynch for Senate poll found that 57 percent of Republican primary voters in South Carolina “would not vote for Lindsey Graham if the election were held today.” When put up against Mark Lynch — a businessman who announced his campaign for Graham’s seat earlier this year — Graham still failed to garner majority support.
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